Table 1 Putative CD4 T cell epitopes of established antigens involved in autoimmune diseases that share similarity with M.tuberculosis proteins.
Protein from M. tuberculosis. | Disease | Homologous Human Proteins (known to be associated with autoimmunity) | Putative T cell epitope | HLA Class II Alleles |
|---|---|---|---|---|
HSP60 | Â | IGAKLVQDVA | HLA DRB1* 01:01 | |
| Â | Â | HSP60 | EGMKFDRGYIS | HLA DRB1* 01:01, 03:01,04:01,07:01,11:01,15:01 |
| Â | Â | Â | VAVKAPGFGD | HLA DRB1*15:01 |
| Â | Â | Â | KPLVIIAEDVDGEALSTLVLN | HLADRB1*01:01,03:01,04:01,07:01,08:02,11:01,13:01,15:01 |
| Â | Â | cDNA FLJ54912 | EGMKFNRGYIS | HLA DRB1*01: 01, 04: 01, 07: 01, 01: 01, 13: 01, 15: 01 |
| Â | Â | Â | KPLVIIAEDVDGEALSTLV | HLA DRB1*01: 01, 03: 01, 04: 01, 07: 01, 08: 02, 11: 01,15: 01 |
| Â | Â | 60 kDa chaperonin (Fragment) [HSPD1] | EGIKFDRGYIS | HLA DRB1*01: 01, 03: 01, 04: 01, 07: 01, 08: 02, 11: 01, 13: 01, 15: 01 |
| Â | Â | Â | LKFDRGYVS | HLA DRB1*01: 01, 03: 01, 04: 01, 07: 01, 11: 01, 13: 01 |
| Â | Putative uncharacterized protein HSPD1 | GEALSTLVLN | HLA DRB1*01: 01 | |
| Â | Â | Â | KPLVIIAEDVDGEALSTLVLN | HLA DRB1*01: 01, 03: 01, 04: 01, 07: 01, 08: 02, 11: 01, 13: 01, 15: 01 |
| Â | Â | T-complex protein 1 subunit beta | LALVTGGEI | HLA DRB1*01: 01, 07: 01, 13: 01, 15: 01 |
| Â | Â | T-complex protein 1 subunit epsilon | LDKISDSVL | HLA DRB1*01: 01, 07: 01 |
Molybdopterin biosynthesis Mog protein | Stiff Man's Syndrome [40] | Gephyrin | LNLILTTGGTG | HLA DRB1*01: 01, 04: 01, 07: 01, 11: 01, 13: 01, 15: 01 |
| Â | Â | Highly similar to Gephyrin | GKTLIINLPGS | HLA DRB1*01: 01, 04: 01, 07: 01, 11: 01, 15: 01 |
Serine/threonine-protein kinase pknD | Paraneoplastic Limbic Encephalitis [49] | BR serine/threonine-protein kinase-2 | HRDLKPENLLL | HLA DRB1*01: 01, 07: 01, 13: 01 |
Isoleucyl-tRNA synthetase | SLE [51] | Isoleucyl-tRNA synthetase | GLPHYGHIL | HLA DRB1*01: 01, 15: 01 |
| Â | Interstitial | Â | Â | Â |