Table 2 Meta-Analysis of COX-2 rs2745557 Polymorphisms and Prostate Cancer
Genetic model (No. of studies) | Sample size | Analysis model | Test of association | Â | P value for Egger's test | Test for heterogeneity | ||
|---|---|---|---|---|---|---|---|---|
| Â | Case | Control | Â | OR (95% CI) | P | Â | P | I2 |
Total (8) | Â | Â | Â | Â | Â | Â | Â | Â |
TT vs CC (5) | 7371 | 7412 | F | 1.04 (0.88-1.23) | 0.66 | 0.510 | 0.74 | 0% |
TC vs CC (5) | 9737 | 9959 | R | 0.88 (0.74-1.04) | 0.14 | 0.275 | 0.05 | 58% |
TT vs TC + CC (5) | 10020 | 10234 | F | 1.06 (0.89-1.25) | 0.51 | 0.627 | 0.81 | 0% |
TT + TC vs CC (8) | 11356 | 11641 | R | 0.85 (0.74-0.97) | 0.02 | 0.062 | 0.01 | 60% |
TC vs TT + CC (5) | 10020 | 10234 | R | 0.88 (0.75-1.04) | 0.13 | 0.276 | 0.06 | 56% |
T vs C (5) | 20040 | 20468 | R | 0.92 (0.80-1.06) | 0.26 | 0.284 | 0.07 | 55% |
Caucasian (6) | Â | Â | Â | Â | Â | Â | Â | Â |
TT vs CC (3) | 7132 | 7024 | F | 1.05 (0.89-1.25) | 0.56 | Â | 0.77 | 0% |
TC vs CC (3) | 9435 | 9446 | R | 0.91 (0.76-1.10) | 0.33 | Â | 0.04 | 68% |
TT vs TC + CC (3) | 9713 | 9709 | F | 1.07 (0.90-1.27) | 0.43 | Â | 0.80 | 0% |
TT+TC vs CC (6) | 11049 | 11116 | R | 0.86 (0.75-0.99) | 0.04 | Â | 0.02 | 64% |
TC vs TT + CC (3) | 9713 | 9709 | R | 0.91 (0.76-1.09) | 0.31 | Â | 0.04 | 68% |
T vs C (3) | 19426 | 19418 | F | 0.97 (0.92-1.03) | 0.32 | Â | 0.11 | 55% |