Table 2 Sensitivity and specificity of ELISA systems for the detection of autoantibodies against collagen VII
Study | Recombinant autoantigen | Commercially available | Sensitivity | Specificity | Reference |
|---|---|---|---|---|---|
Chen et al. (n = 24) | NC1 domain | No | 100% | - | [22] |
Pendaries et al. (n = 41) | Collagen VII full length | No | 68% | 96% | [25] |
Saleh et al. (n = 49) | NC1 + NC2 | Yes | 93.8% | 98.1% | [26] |
Komorowski et al.(n = 73) | NC1 domain | Yes | 91.8% | 99.8% | [27] |
Licarete et al. (n = 50) | NC1-hinge-NC2 | - | 94% | 98% | present study |