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Table 1 Top 10% DE genesa in growing feathers from SL chickens relative to non-vitiliginous parental BL controls

From: Understanding mechanisms of vitiligo development in Smyth line of chickens by transcriptomic microarray analysis of evolving autoimmune lesions

GeneName/Symbol

Up-regulated DE genes

GeneName/Symbol

Down-regulated DE genes

NV b

   

IGJ

+5.99c

Lipoprotein VSAF

-11.51

CHIA

+5.29

MMP9

-7.81

similar to TCR delta chain

+3.67

similar to GHITM protein

-5.02

COBT

+3.58

TMEM22

-3.09

RSFR

+2.82

HVCN1

-3.00

CCL19

+2.79

HNRPU protein

-2.64

similar to CXCL13

+2.72

MMP13

-2.64

GBP

+2.69

similar to keratin

-2.49

MX

+2.64

FMO6

-2.46

similar to MMR (CD206)

+2.63

HIST2H3C protein

-2.45

similar to MSTP055

+2.61

ASB12

-2.38

similar to T-cell receptor gamma Vg2-Jg2

+2.60

altronate hydrolase

-2.35

GZMA

+2.60

GOLGB1

-2.34

TMED8

+2.53

RuBisCu

-2.27

ISG12-2

+2.50

LEPREL1

-2.21

EV

   

similar to CXCL13

+16.01

Lipoprotein VSAF

-12.05

GBP

+12.08

MMP9

-5.15

LITAF

+10.08

similar to keratin

-5.11

TNFSF13B

+9.77

PTH

-4.88

similar to sodium channel alpha subunit

+8.74

Adenine phosphoribosyltransferase

-3.51

CCL19

+8.17

similar to GHITM protein

-3.44

GZMA

+7.41

HIST2H3C protein

-3.15

IL21R

+7.41

FMO6

-2.94

C3AR1

+7.15

TAC1

-2.83

CHIA

+7.03

KCNE1L

-2.82

similar to immune-responsive protein 1

+6.71

SLC22A5

-2.79

ISG12-2

+6.67

GOLGB1

-2.73

Chemokine ah294

+6.43

TMEM22

-2.70

MX

+6.17

MMP13

-2.64

TLR15

+6.15

FCGBP

-2.46

similar to MD-2

+6.12

HNRPU protein

-2.43

IGJ

+6.04

Cytochrome b

-2.38

Mucolipin 2

+6.03

similar to CLIC3

-2.34

Gp91-phox

+5.91

HVCN1

-2.34

similar to IFIT-5

+5.89

Probable G protein-coupled receptor 26

-2.27

IRF1

+5.85

Thrombomucin

-2.24

AV

   

similar to sodium channel alpha subunit

+17.96

PTH

-11.70

IGJ

+17.84

Lipoprotein VSAF

-11.50

similar to CXCL13

+17.13

SLC24A5

-7.23

POU2AF1

+16.37

MMP9

-6.02

TNFSF13B

+16.01

MMP115

-5.57

LITAF

+14.92

similar to GHITM protein

-4.57

LECT2

+11.20

Adenine phosphoribosyltransferase

-4.38

similar to immune-responsive protein 1

+10.94

similar to keratin

-4.13

IL21R

+10.80

CRYAB

-3.78

Gp91-phox

+10.58

TMEM22

-3.61

Mucolipin 2

+10.58

KCNE1L

-3.46

C3AR1

+10.32

Shikimate 5-dehydrogenase

-3.39

GBP

+10.23

TAC1

-3.16

Myeloid antimicrobial peptide 27

+9.38

FMO6

-2.74

LYZ

+8.92

UPK3B

-2.62

similar to MD-2

+8.73

MRRF

-2.60

similar to regulator of G-protein signaling 1

+8.65

MMP13

-2.60

TLR15

+8.32

similar to ALS2

-2.49

CCL19

+7.72

HIST2H3C protein

-2.45

CHIA

+7.65

TYR

-2.42

C-C chemokine receptor 11 like

+7.59

SLC22A5

-2.42

CV

   

IGJ

+20.76

SLC24A5

-17.06

POU2AF1

+18.19

TYR

-15.54

Myeloid antimicrobial peptide 27

+13.31

MMP115

-14.01

similar to sodium channel alpha subunit

+12.53

Lipoprotein VSAF

-12.43

LECT2

+11.91

PTH

-11.89

similar to CXCL13

+8.94

MMP9

-6.95

CHIA

+7.39

CRYAB

-5.09

TNFSF13B

+7.10

Shikimate 5-dehydrogenase

-4.83

GBP

+6.43

similar to GHITM protein

-4.28

C-C chemokine receptor 11 like

+6.42

similar to keratin

-3.39

GAL7

+6.04

TAC1

-3.38

LITAF

+5.82

similar to ALS2

-3.17

Cytochrome b

+5.30

TMEM22

-2.95

C3AR1

+5.09

HVCN1

-2.90

similar to regulator of G-protein signaling 1

+5.00

MMP13

-2.83

MX

+4.96

similar to EPHX1 protein

-2.66

LYZ

+4.40

VSX1

-2.55

GPR174

+4.21

GOLGB1

-2.54

IL21R

+4.11

FMO6

-2.47

similar to MSTP055

+3.99

HIST2H3C

-2.46

ISG12-2

+3.91

similar to BTBD7

-2.45

  1. a: DE genes without gene information, from cDNA clones and of hypothetic proteins were deleted. The whole list of DE genes for all SL samples before deletion is available upon request
  2. b: NV indicates that feather samples were from SL chickens that never developed vitiligo; EV, AV, and CV indicates growing feathers were from SL chickens with vitiligo (SLV) before, during and after complete loss of pigmentation
  3. c: numbers in the body of the table are fold changes relative to gene expression levels in samples from BL (the parental line) chickens. For comparison purpose, the data obtained from the microarray analysis for down-regulated genes (< 1) were expressed as fold changes by calculation: the ratio of 1 to the number (e.g. for DE value of 0.12 the fold change would be 8.3; i.e. 1/0.12). Up- and down-regulated DE genes were indicated by a positive and negative sign, respectively
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BMC Immunology

ISSN: 1471-2172

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