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Figure 1 | BMC Immunology

Figure 1

From: Tissue transglutaminase treatment leads to concentration-dependent changes in dendritic cell phenotype - implications for the role of transglutaminase in coeliac disease

Figure 1

Analysis of DC phenotype following treatment with ECM proteins. (A) Flow cytometric analysis of the phenotype of untreated (control) DCs following culturing for 48 h (upper panel) and 72 h (lower panel). The filled histograms represent isotype or unstained controls, unfilled histograms show staining of named markers. The numbers are MFI values of a representative experiment (B) Phenotype of DCs untreated (CTRL) or treated with 0.01% FN, TG [high], TG [mid] or TG [low] for 48 h (upper panel) and 72 h (lower panel), (n = 3). MFI values for the indicated antigens are depicted as a percentage of the CTRL value. TG-2 activity defined as 0.039 U/mL (TG-2 [high]), 0.0036 U/mL (TG-2 [mid]) or 0.00022 U/mL (TG-2 [low]). Error bars represent standard deviations and * p < 0.05, ** p < 0.01, *** p < 0.001. NB: n = 2 for CD54 expression.

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BMC Immunology

ISSN: 1471-2172

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