Tissue transglutaminase treatment leads to concentration-dependent changes in dendritic cell phenotype - implications for the role of transglutaminase in coeliac disease

Table 1 A summary of the effects of ECM protein treatment on DC phenotype, morphology and function

	FN	TG [high]	TG [mid]	TG [low]
*Surface marker profile*
Antigen-presentation (HLA-DR)	-	↑*⁷²	-	↓*⁴⁸
Co-stimulation (CD86)	-	-	↓*⁴⁸	↓*
Endocytosis (CD206)	-	-	-	-
Maturity (CD83)	-	↑*⁷²	-	-
Adhesion (CD54)	↑	-	↓	↓*⁷²
*Morphology*	-	Mature	-	Immature
*Function*
Endocytic ability	↑	-	↑*	↑*
T-cell stimulation	-	↑	↓	↓
T-cell polarisation	-	Effector	Tolerance	-

* indicates that change was significantly different from the control. For phenotypic results, *48 indicates significance only at 48 h, *72 indicates significance only at 72 h

ISSN: 1471-2172