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Table 2 Spearman’s rank correlation coefficient (with p-value) between antibacterial activity of peptides and their physicochemical characterization including data from experiments carried out in this paper and by other authors

From: Innate immune properties of selected human neuropeptides against Moraxella catarrhalis and nontypeable Haemophilus influenzae

Physicochemical characteristics

Peptide set analysed in:

 

this paper

[21]

[23]

length

−0.44 (0.044)

−0.33 (0.174)

−0.25 (0.555)

molecular mass

−0.69 (0.000)

−0.42 (0.085)

0.27 (0.515)

isoelectric point

0.31 (0.164)

−0.78 (0.000)

−0.27 (0.515)

charge

0.32 (0.160)

−0.48 (0.043)

−0.94 (0.001)

polarity

−0.91 (0.000)

0.79 (0.000)

0.32 (0.438)

hydropathicity

0.57 (0.006)

−0.14 (0.572)

−0.91 (0.002)

transmembrane tendency

0.82 (0.000)

−0.79 (0.000)

−0.64 (0.086)

α-helix tendency

0.31 (0.170)

−0.58 (0.012)

−0.02 (0.954)

β-sheet tendency

0.41 (0.063)

−0.66 (0.003)

−0.91 (0.002)

maximum hydrophobic moment

−0.72 (0.000)

0.26 (0.306)

0.32 (0.438)

non-polar residues [%]

0.70 (0.000)

−0.13 (0.600)

0.15 (0.726)

polar residues [%]

−0.41 (0.063)

0.13 (0.600)

−0.15 (0.726)

basic residues [%]

−0.23 (0.316)

0.44 (0.065)

−0.02 (0.954)

acidic residues [%]

−0.79 (0.000)

0.38 (0.123)

0.32 (0.438)

  1. The data from experiments performed on different bacteria but for the same or overlapping set of peptides’ set were min-max normalized and included in one analysis. For further explanation see Materials and Methods. Results significant with p-value < 0.05 were shown in bold.