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Table 2 The genotype and allelic frequencies and carriage rates of six investigated single nucleotide polymorphisms (SNPs) of cytokine genes in 1) patients that developed prosthetic joint infection after total joint arthroplasty (TJA with PJI, N = 89), 2) patients without prosthetic infection (TJA without PJI, N = 214) and 3) the group of healthy control subjects (N = 168)

From: Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection

 

TJA with PJI

TJA without PJI

Healthy Controls (HC)

  

Genotype frequencies

 

Allelic frequencies

 

Carriage rates

 

Genotype frequencies

 

Allelic frequencies

 

Carriage rates

 

Genotype frequencies

 

Allelic frequencies

 

Carriage rates

IL1B-511*

CC

0.31

C

0.61

C

0.91

CC

0.49

C

0.69

C

0.90

CC

0.45

C

0.68

C

0.91

 

CT

0.60

    

CT

0.42

    

CT

0.46

    
 

TT

0.09

T

0.39

T

0.69

TT

0.10

T

0.31

T

0.51

TT

0.09

T

0.32

T

0.55

IL1B  + 3962

CC

0.59

C

0.76

C

0.94

CC

0.57

C

0.75

C

0.92

CC

0.61

C

0.78

C

0.96

 

CT

0.35

    

CT

0.35

    

CT

0.35

    
 

TT

0.06

T

0.24

T

0.41

TT

0.08

T

0.25

T

0.43

TT

0.04

T

0.22

T

0.39

TNF-308

GG

0.74

G

0.85

G

0.96

GG

0.72

G

0.85

G

0.97

GG

0.68

G

0.83

G

0.98

 

GA

0.21

    

GA

0.25

    

GA

0.30

    
 

AA

0.04

A

0.15

A

0.26

AA

0.03

A

0.15

A

0.28

AA

0.02

A

0.17

A

0.32

TNF-238

GG

0.91

G

0.96

G

1.00

GG

0.93

G

0.96

G

1.00

GG

0.92

G

0.96

G

1.00

 

GA

0.09

    

GA

0.07

    

GA

0.08

    
 

AA

0.00

A

0.04

A

0.09

AA

0.00

A

0.04

A

0.07

AA

0.00

A

0.04

A

0.08

IL6–174

GG

0.33

G

0.56

G

0.79

GG

0.36

G

0.58

G

0.79

GG

0.33

G

0.58

G

0.84

 

GC

0.46

    

GC

0.43

    

GC

0.51

    
 

CC

0.21

C

0.44

C

0.67

CC

0.21

C

0.42

C

0.64

CC

0.16

C

0.42

C

0.67

IL6 nt565

GG

0.34

G

0.57

G

0.80

GG

0.38

G

0.59

G

0.81

GG

0.33

G

0.59

G

0.85

 

GA

0.46

    

GA

0.43

    

GA

0.52

    
 

AA

0.20

A

0.43

A

0.66

AA

0.19

A

0.41

A

0.62

AA

0.15

A

0.41

A

0.67

  1. The data are presented as relative values.
  2. * IL1B-511*T carriage rate (Pearson’s Chi-square test, 1 degree of freedom, d.f.):
  3. TJA with PJI versus TJA without PJI: p = 0.006, pcorr = 0.037; odds ratio = 2.06, 95%CI: 1.22-3.47.
  4. TJA with PJI versus HC: p = 0.04, pcorr > 0.05; odds ratio = 1.76, 95%CI: 1.02-3.02.
  5. * Distribution of IL1B-511 genotypes (Pearson’s Chi-square test, 2 d.f.):
  6. TJA with PJI versus TJA without PJI: p = 0.014, pcorr > 0.05.
  7. * Allelic frequency of IL1B-511*T (Pearson’s Chi-square test, 1 d.f.):
  8. TJA with PJI versus TJA without PJI: p = 0.052.
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BMC Immunology

ISSN: 1471-2172

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