Table 3 Estimated frequencies of IL1B, TNF and IL6 two-locus (SNP) haplotypes in patients with prosthetic joint infection after total joint arthroplasty (TJA with PJI), those without infection (TJA without PJI) and Czech healthy controls. Data are given as proportions (relative numbers) of each possible haplotype

IL1B haplotypes

−511 / +3962

CC

0.398

0.476

0.479

CT

0.214

0.217

0.195

TC

0.367

0.272

0.304

TT

0.022

0.035

0.022

Overall LD p value

0.003

0.001

0.002

TNF haplotypes

−308 / -238

AG

0.107

0.152

0.170

GA

0.045

0.040

0.042

GG

0.848

0.808

0.789

AA

0.000

0.000

0.000

Overall LD p value

0.607

0.289

0.017

IL6 haplotypes

−174 / nt565

CA

0.433

0.407

0.411

CG

0.011

0.016

0.006

GG

0.556

0.577

0.580

GA

0.000

0.000

0.003

Overall LD p value

<0.00001

<0.00001

<0.00001