TY - JOUR AU - Chauncey, Kassidy M. AU - Lopez, M. Cecilia AU - Sidhu, Gurjit AU - Szarowicz, Sarah E. AU - Baker, Henry V. AU - Quinn, Conrad AU - Southwick, Frederick S. PY - 2012 DA - 2012/07/02 TI - Bacillus anthracis’ lethal toxin induces broad transcriptional responses in human peripheral monocytes JO - BMC Immunology SP - 33 VL - 13 IS - 1 AB - Anthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis, is a highly effective zinc dependent metalloprotease that cleaves the N-terminus of mitogen-activated protein kinase kinases (MAPKK or MEKs) and is known to play a role in impairing the host immune system during an inhalation anthrax infection. Here, we present the transcriptional responses of LT treated human monocytes in order to further elucidate the mechanisms of LT inhibition on the host immune system. SN - 1471-2172 UR - https://doi.org/10.1186/1471-2172-13-33 DO - 10.1186/1471-2172-13-33 ID - Chauncey2012 ER -