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Table 2 Predicted effects of LT on monocyte function.1

From: Bacillus anthracis’ lethal toxin induces broad transcriptional responses in human peripheral monocytes

Gene Microarray Effects
RGS-14 5.61 Blockade of monocyte maturation to dendritic cells, inhibition of chemotaxis
CXCR2 5.04 Increased monocyte transendothelial migration into tissues
HPSE -2.58 Diminished inflammatory response
CCR5 -2.33 Reduced responsiveness to the inflammatory mediators RANTES, MIP1 beta
ILIR2 -12.5 Increased IL1 alpha responsiveness and increased fever
  1. 1 Calculated fold changes compared to mock treated samples.