Differences in histologic parameters between the two intestinal injury models post cessation of DSS treatments. Wild-type mice were treated with 3% (A, C, E) or 1% (B, D, F) DSS as described in Figure 1. Colons were collected from mice on days 0 (A, B), 7 (C, D), and 14 (E, F). Histopathologic changes in individual crypts (20x dry objective, scale bars = 100 μm) are shown in representative H&E-stained sections. Loss of crypt architecture associated with epithelial damage (white arrows) and leukocyte infiltration (black arrows) is observed following DSS treatment.