Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases

BMC Immunology

Table 1 Effect of DSS concentrations in wild-type mice

Treatment^a	N	Disease activity acore	Histologic score
Untreated wild-type	6	0.2 ± 0.2	0.0 ± 0.0
1% DSS wild-type day 7	6	2.3 ± 0.6^b	1.8 ± 0.4^b
1% DSS wild-type day 14	6	0.2 ± 0.2	0.3 ± 0.2
3% DSS wild-type day 7	5	11.6 ± 0.2^b	4.4 ± 0.5^b
3% DSS wild-type day 14	5	2.8 ± 1.0^b	3.8 ± 0.4^b

^aMice were treated with 1 or 3% DSS in their drinking water for seven days then administered regular drinking water for an additional seven days. Clinical and histological parameters were recorded on days 7 and 14 as described in the materials and methods. Results are the mean ± standard error of the means.
^bSignificantly different from untreated wild-type mice (p < 0.05; Mann–Whitney test).

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