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Table 1 Effect of DSS concentrations in wild-type mice

From: Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases

Treatmenta N Disease activity acore Histologic score
Untreated wild-type 6 0.2 ± 0.2 0.0 ± 0.0
1% DSS wild-type day 7 6 2.3 ± 0.6b 1.8 ± 0.4b
1% DSS wild-type day 14 6 0.2 ± 0.2 0.3 ± 0.2
3% DSS wild-type day 7 5 11.6 ± 0.2b 4.4 ± 0.5b
3% DSS wild-type day 14 5 2.8 ± 1.0b 3.8 ± 0.4b
  1. aMice were treated with 1 or 3% DSS in their drinking water for seven days then administered regular drinking water for an additional seven days. Clinical and histological parameters were recorded on days 7 and 14 as described in the materials and methods. Results are the mean ± standard error of the means.
  2. bSignificantly different from untreated wild-type mice (p < 0.05; Mann–Whitney test).