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Table 3 Monocyte-Derived Macrophages response t o in vitro stimulation

From: The peritoneal macrophage inflammatory profile in cirrhosis depends on the alcoholic or hepatitis C viral etiology and is related to ERK phosphorylation

Cytokines

Etiology

 

Fold activation

  

LPS

ODN

C. albicans

TNF-α

ALC-C

89.26 (204.5) a

0.89 (1.7)

170.92 (374.6) a

 

HCV-C

97.61 (163.9) a

2.42 (4.9)

4334.96 (595.4) a

IL-6

ALC-C

2.73 (3.5) a

0.84 (5.8)

3.35 (10.4) a

 

HCV-C

5.97 (19.6) *,a

1.26 (7.2)*,a

5.68 (37.2) *,a

IL-10

ALC-C

9.06 (6.2)a

0.77 (0.6)

13.7 (24.5) a

 

HCV-C

11.33 (13.9) a

1.4 (2.6) *,a

223.4 (45.3) a

IL-12

ALC-C

1.75 (3.4) a

2.1 (8.4)

3.7 (6.6) a,*

 

HCV-C

3.15 (4.8)

6.6 (17.4)

1.93 (1.1)

IL-1β

ALC-C

20.21 (63) a

1.5 (10)

46.85 (135.6) a

 

HCV-C

10.89 (24.7) a

2.11 (2.73)

15.4 (28.5) a

  1. Results are expressed as median (interquartile range). Mann–Whitney U test: * P < 0.05 between ALC-C and HCV-C; Wilcoxon signed-rank test: a P <0.05 between control and treatments.