Table 2 Intracellular and plasma cytokines and chemokines by age, analyzed by multivariate random-effect models estimated by stepwise procedure and adjusted by previous episodes, current infection, IPTi treatment, gender and neighborhood of residence.

Intracellular

IFN-γ

5

1

-

-

< 0.0001

9

0.36

0.26; 0.48

< 0.0001

12

0.41

0.29; 0.57

< 0.0001

24

0.32

0.23; 0.45

< 0.0001

IL-10

5

1

-

-

< 0.0001

9

0.45

0.37; 0.55

< 0.0001

12

0.63

0.50; 0.78

< 0.0001

24

0.92

0.74; 1.15

0.4700

Plasma

IL-2

5

1

-

-

< 0.0001

9

0.74

0.58; 0.95

0.0193

12

0.47

0.37; 0.60

< 0.0001

24

0.38

0.29; 0.51

< 0.0001

IL-12

5

1

-

-

0.0001

9

0.87

0.69; 1.10

0.2428

12

0.63

0.50; 0.79

0.0001

24

1.02

0.79; 1.31

0.9070

IFN-γ

5

1

-

-

< 0.0001

9

0.84

0.59; 1.21

0.3510

12

0.43

0.30; 0.61

< 0.0001

24

0.69

0.47; 1.03

0.0703

IL-1β

5

1

-

-

< 0.0001

9

0.30

0.22; 0.40

< 0.0001

12

0.36

0.27; 0.48

< 0.0001

24

0.51

0.38; 0.70

< 0.0001

IL-6

5

1

-

-

0.0001

9

0.51

0.38; 0.68

< 0.0001

12

0.65

0.49; 0.87

0.0032

24

0.75

0.55; 1.03

0.0806

TNF

5

1

-

-

< 0.0001

9

0.54

0.39; 0.73

0.0001

12

0.39

0.29; 0.53

< 0.0001

24

0.21

0.15; 0.30

< 0.0001

IL-4

5

1

-

-

< 0.0001

9

0.69

0.53; 0.90

0.0073

12

0.54

0.41; 0.71

< 0.0001

24

0.31

0.23; 0.41

< 0.0001

IL-5

5

1

-

-

0.0001

9

0.88

0.75; 1.04

0.1450

12

0.68

0.58; 0.81

< 0.0001

24

0.77

0.65; 0.93

0.0056

IL-13

5

1

-

-

< 0.0001

9

0.77

0.64; 0.92

0.0045

12

0.58

0.49; 0.70

< 0.0001

24

1.59

1.30; 1.94

< 0.0001

IL-10

5

1

-

-

< 0.0001

9

0.85

0.71; 1.03

0.0941

12

0.60

0.50; 0.73

< 0.0001

24

0.53

0.43; 0.66

< 0.0001

IL-7

5

1

-

-

< 0.0001

9

0.99

0.86; 1.15

0.9244

12

0.74

0.64; 0.86

< 0.0001

24

0.66

0.56; 0.77

< 0.0001

IL-17

5

1

-

-

< 0.0001

9

0.68

0.54; 0.85

0.0009

12

0.63

0.50; 0.79

0.0001

24

1.05

0.82; 1.35

0.6774

G-CSF

5

1

-

-

< 0.0001

9

0.77

0.64; 0.91

0.0032

12

0.64

0.53; 0.76

< 0.0001

24

1.50

1.24; 1.81

< 0.0001

GM-CSF

5

1

-

-

< 0.0001

9

0.78

0.56; 1.09

0.1525

12

0.49

0.35; 0.68

< 0.0001

24

0.52

0.36; 0.75

0.0004

MCP-1

5

1

-

-

< 0.0001

9

0.92

0.80; 1.06

0.2724

12

0.80

0.70; 0.93

0.0025

24

1.22

1.04; 1.42

0.0156

MIP-1β

5

1

-

-

< 0.0001

9

0.68

0.58; 0.80

< 0.0001

12

0.85

0.73; 1.00

0.0437

24

0.98

0.82; 1.16

0.7803

IL-8

5

1

-

-

0.0003

9

0.60

0.47; 0.77

0.0001

12

0.94

0.73; 1.20

0.6171

24

0.89

0.68; 1.17

0.3991