Figure 3

Shannon entropy values (top panels) and amino acid frequencies (bottom panels) of unique CDR1 (A) and CDR2 (B) sequences identified by Paratome from all repertoires examined. The most common CDR2 length class (13 amino acids) is shown. X-axis values are amino acid positions from the start of framework region 1 with each bar representing 100% of the amino acids identified at that position. Amino acids are grouped according to hydrophobicity with charged amino acids at the bottom and hydrophobic amino acids at the top.