Figure 7
(A-B) Bacterial load in spleen and kidneys of animals (24/groups) infected with Staphylococcus epidermidis (107 CFU/mouse; rumble line); infected with Staphylococcus epidermidis(107 CFU/mouse) and treated with the MIX (RJI-C at 9 μg/mouse and TB-KK at 6 μg/mouse; square line) or gentamicin (5 μg/mouse; triangle line) *P <0.05, **p < 0.01; ***p < 0.001, Student’s t test gentamicin vs MIX. (C) TNF-α, IFN-γ, IL-10 mRNA expression levels were quantified, at the indicated time points, in mice infected with Staphylococcus epidermidis (107 CFU/mouse) or infected with Staphylococcus epidermidis (107 CFU/mouse) and treated with three different doses (I,II,III) of the MIX (RJI-C at 9 μg in 100 μl/mouse and TB-KK at 6 μg in 100 μl/mouse) or gentamicin (5 μg in 100 μl/mouse). Values were normalized with GAPDH and compared to untreated control. *P <0.05, **p < 0.01; ***p < 0.001, Student’s t test gentamicin vs MIX.