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Table 1 Six well studied HLA class I- and seven class II- restricted HCV immunodominant epitope sequences were chosen from previous publications for this study

From: Sequence-based in silico analysis of well studied Hepatitis C Virus epitopes and their variants in other genotypes (particularly genotype 5a) against South African human leukocyte antigen backgrounds

CLASS I EPITOPES SEQUENCE (Subtype) RESTRICTION REFERENCE NUMBER OF REFERENCES LISTED AT IEDB
NS3 1073-1081 CINGVCWTV (1a) A02 [20, 21] 78
NS3 1406-1415 KLVALGINAV (1a) A02 [22, 23] 70
NS4 1807-1816 LLFNILGGWV (1a) A02 [24, 25] 39
NS4 1851-1859 ILAGYGAGV (1) A02 [22] 29
NS5B 2422-2433 MSYSWTGALVTP (1) B15 [22] 1
NS5B 2727-2735 GLQDCTMLV (1) A02 [22] 22
CLASS II     
Core 17-35^ RRPQDVKFPGGGQIVGGVY (1) Undetermined Class II allele [26] 1
Core 21-40^ DVKFPGGGQIVGGVYLLPRR (1) HLA-DRB1*1501 [21, 26, 27] 13
NS3 1248-1261 GYKVLVLNPSVAAT (1) HLA-DRB1*1201; 1101; 1301; 0401 [21, 25, 28] 5
NS4A 1781-1800 LPGNPAIASLMAFTAAVTSP (1a) Undetermined Class II allele [25] 3
NS4A 1801-1820 LTTSQTLLFNILGGWVAAQL (1a) Undetermined Class II allele [25, 27, 29] 4
NS5 2571-2590 KGGRKPARLIVFPDLGVRVC (1a) Undetermined Class II allele [4, 25, 27, 29] 4
NS5 2661-2680 QCCDLDPQARVAIKSLTERL (1a) Undetermined Class II allele [27, 29] 4
  1. ^Class II- restricted epitopes in the core region are overlapping sequences.