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Table 1 Six well studied HLA class I- and seven class II- restricted HCV immunodominant epitope sequences were chosen from previous publications for this study

From: Sequence-based in silico analysis of well studied Hepatitis C Virus epitopes and their variants in other genotypes (particularly genotype 5a) against South African human leukocyte antigen backgrounds

CLASS I EPITOPES

SEQUENCE (Subtype)

RESTRICTION

REFERENCE

NUMBER OF REFERENCES LISTED AT IEDB

NS3 1073-1081

CINGVCWTV (1a)

A02

[20, 21]

78

NS3 1406-1415

KLVALGINAV (1a)

A02

[22, 23]

70

NS4 1807-1816

LLFNILGGWV (1a)

A02

[24, 25]

39

NS4 1851-1859

ILAGYGAGV (1)

A02

[22]

29

NS5B 2422-2433

MSYSWTGALVTP (1)

B15

[22]

1

NS5B 2727-2735

GLQDCTMLV (1)

A02

[22]

22

CLASS II

    

Core 17-35^

RRPQDVKFPGGGQIVGGVY (1)

Undetermined Class II allele

[26]

1

Core 21-40^

DVKFPGGGQIVGGVYLLPRR (1)

HLA-DRB1*1501

[21, 26, 27]

13

NS3 1248-1261

GYKVLVLNPSVAAT (1)

HLA-DRB1*1201; 1101; 1301; 0401

[21, 25, 28]

5

NS4A 1781-1800

LPGNPAIASLMAFTAAVTSP (1a)

Undetermined Class II allele

[25]

3

NS4A 1801-1820

LTTSQTLLFNILGGWVAAQL (1a)

Undetermined Class II allele

[25, 27, 29]

4

NS5 2571-2590

KGGRKPARLIVFPDLGVRVC (1a)

Undetermined Class II allele

[4, 25, 27, 29]

4

NS5 2661-2680

QCCDLDPQARVAIKSLTERL (1a)

Undetermined Class II allele

[27, 29]

4

  1. ^Class II- restricted epitopes in the core region are overlapping sequences.