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Table 4 Binding affinity scores of “newly predicted” epitopes and their variants were determined by the IEDB prediction program to relevant supertypes in South Africa

From: Sequence-based in silico analysis of well studied Hepatitis C Virus epitopes and their variants in other genotypes (particularly genotype 5a) against South African human leukocyte antigen backgrounds

GENE EPITOPE SEQUENCE GENOTYPE OF EPITOPE   Class A- Alleles Class B- Alleles
    Supertypes A01 A02 A24 A01A03 A01A24 B07 B58 B27
    Allele type A*01:01 A*02:01 A*68:02 A*23:01 A*30:01 A*29:02 B*07:02 B*35:01 B*53:01 B*57:01 B*58:01 B*15:03 B*27:05
NS3 LTGPTPLLY 5a, 1b   15 23679 24474 24873 4551 5 24599 6188 7688 448 28 1558# 22842
  LHGPTPLLY 1a   10396 24884 27469 21381 17350 10 26731 12561 6443 21175 9987 442 23420
  FLSTATQTF 5a   165 15329 17845 3634 1663 1886 15839 40 17977 16320 4231 8 18662
  IVSTAAQTF 1a   20409 23323 22013 4758 11756 5496 11246 75 13372 814# 425 55 22273
  VLSTVTQSF 1b, 2a   18550 13712 17004 4838 16940 5785 15666 988# 29052 11492 1654 26 21745
  IVSTDTQSF 4a   19885 22289 20020 12440 14943 5300 6080 151 8229 4394 973# 47 24757
  TLAGPKGPV 5a, 6a   23444 2081# 13 33957 16907 18949 6657 21854 39095 25027 22108 20499 22034
  TLASPRGPV 1b   22044 1451# 8 32375 13790 18855 2453 21660 39379 25346 22237 6235 22501
  TLASSRGPV 2a   22034 857# 11 29481 9965 20464 2095 19022 38571 24511 22225 3353 22267
  TLASAKHPA 3a   21914 413 49 29038 10681 19694 16284 12935 39038 24637 21967 13015 23364
  TIASPKGPV 1a   22885 7397 7 34010 15054 20663 7437 19533 38620 25493 22070 16303 24145
  SVIDCNSAV 5a   21948 30 9 24435 8789 12923 1702 4571 35486 21627 21514 3381 25586
  SVTDCNTCV 1b   21476 131 24 30991 15202 21169 19345 15846 19349 26045 22021 11521 22609
  SVIDCNVAV 1b, 2a, 6a   21855 15 6 22019 7833 13308 3218 4376 31399 24317 21463 3412 24232
  SVIDCNTCV 1a   22281 25 13 23478 14812 17452 17390 13879 20769 25334 21666 7032 23918
  SVIDCNTSV 4a   22543 18 9 25166 10636 15522 3402 11164 17097 24124 20942 4646 24512
  ITYSTYGKF 1b, 5a, 2a, 2b, 1a, 4a   16829 22979 16133 124 9722 352 21954 6132 16141 354 43 27 20982
  LTYSTYGKF 3a   14296 22834 13829 263 10036 379 22076 3345 11660 860# 41 31 20046
  KVLVLNPSV 1a, 1b, 2a, 2b, 4a, 5a, 6a   23587 50 6303 27046 21 18669 14670 21450 31145 20648 8842 3129# 18558
  RAKAPPPSW 5a, 1b, 2a, 6a   25817 25080 27568 8387 308 25791 7172 18126 8580 31 11 596# 22382
  RAQAPPPSW 1b, 3a, 1a   24980 24747 27454 22992 6443 24136 6017 14212 3253 38 8 1675# 17482
  KVWLAPPPSW 4a   24000 4927 22172 26746 170 16220 18770 9620 39029 21580 20215 12296 20633
  LTSLGVNAV 5a   5815 3795 42 33629 6533 20008 16663 13886 27357 24243 18277 3860# 24767
  LTSLGLNAV 5a variant   5305 3082 64 32917 6065 18186 16615 16431 29952 24579 19519 7004 23118
  1. <50 IC50nm, bold, high affinity.
  2. >50 IC50nm, <500 IC50nm, italic, intermediate affinity.
  3. >500 IC50nm, #, poor affinity.