Figure 4

Synergistic interaction of CD4+ T cell proliferation between two epitopes. CD4+ T cells primed with rLpp20 were tested in a proliferation assay for responses to peptide L1, L2, pooled L1 and L2 (1.25 μg/ml) and rLpp20 (15 μ g/ml). Response to the antigen was expressed as the mean SI of three independent experiments ± S.D. The medium with rLpp20 was served as positive control and without any antigen weas used as negative control. The pooled peptides was significantly different from individual peptide (*p < 0.05). The values shown were means ± SD of three experiments.