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Figure 1 | BMC Immunology

Figure 1

From: Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum

Figure 1

Serum IgG levels of healthy individuals. The concentrations of serum IgG were measured by turbidimetric immunoassay. CD72 IVS8-VNTR which was the tag polymorphism for human CD72 haplotypes was genotyped by PCR–simple sequence length polymorphism (SSLP) method, and FCGR2B-Ile232Thr was genotyped by nested PCR and fluorescence resonance energy transfer (FRET) technology. The concentrations of serum IgG were compared among CD72 genotypes (A) or FCGR2B genotypes (B). The serum IgG levels were compared among individuals with CD72*1/1, those with CD72*1/2 and those with CD72*2/2 by Kruskal-Wallis rank sum test, and P-value indicates the estimated probability of rejecting the null hypothesis that rank sum of the serum IgG levels among different CD72 haplotypes are not different; P < 0.05. Additionally, concordance to the model in which the serum IgG levels are in proportion to the number of CD72*1 haplotype was examined by regression analysis, and P-value indicates the estimated probability of rejecting the null hypothesis that serum IgG levels were not in proportion to the number of CD72*1 haplotype; P < 0.01.

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BMC Immunology

ISSN: 1471-2172

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