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Figure 4 | BMC Immunology

Figure 4

From: IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme

Figure 4

Th differentiation in the absence of BAF180 A) Scheme for differentiation of T helper cells in culture, and restimulation with PMA/ionomycin. B) Th1 cytokine and transcription factor expression as assessed by real time RT-PCR in WT and BAF180-/- stimulated Th1 cells. C) Th2 cytokine and transcription factor expression as assessed by real time RT-PCR comparing WT and BAF180-/- stimulated Th2 cells. D) Th17 cytokine and transcription factor expression as assessed by real time RT-PCR in WT and BAF180-/- stimulated Th17 cells. Results are the average and standard deviation of four independent experiments. The change in IL-10 was statistically significant (p < 0.005), the change in IL-4 was significant (p < 0.05) while none of the other tests here were significant.

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