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Figure 9 | BMC Immunology

Figure 9

From: IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme

Figure 9

Enhanced histone acetylation and CBP recruitment to IL-10 locus in BAF180-deficient Th2 cells Histone modifications and binding of the histone acetyltransferase CBP were detected by ChIP-PCR at the indicated sites in the IL-10 locus. Signal is expressed as percent of the input chromatin. Control IP levels are less than 0.05% input. Nfm is a locus in the neuron-specific medium neurofilament gene, a binding site for BRG1 in neurons and brain but not in T cells. The results are the average and standard deviation of three ChIP experiments. A) Histone H3K4 monomethylation. B) Histone H3K18 acetylation. C) CBP binding. D) Histone H3K9 acetylation.

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