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Table 1 Clinical, demographic and laboratory characteristics of the study participants

From: Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels

Characteristics non-SMA (Hb ≥ 6.0 g/dL) SMA (Hb < 6.0 g/dL) P value
No. of participants (n = 387) 222 165  
Gender, n (%)    
 Male 115 (51.8) 84 (50.9) 0.862a
 Female 107 (48.2) 81 (49.1)
Age, months 11.0 (10.0) 8.0 (8.0) <0.001 b
IL-13 concentration (pg/mL) 31.6(26.5) 35.4(38.07) 0.415b
Parasites/μL 29960.1(40957.8) 20639.1(42359.6) 0.530b
Hematological Parameters
Hemoglobin, g/dL 8.0 (3.0) 4.9 (1.0) <0.001 b
Hematocrit,% 24.8 (7.3) 15.8 (5.0) <0.001 b
RBCs, × 1012/μL 3.7 (1.2) 2.2 (0.9) <0.001 b
RDW,% 17.5 (1.7) 17.9 (1.2) <0.001 b
MCHC, g/L 32.3 (2.0) 31.3 (2.7) <0.001 b
  1. Data is presented as the median (interquartile range) unless stated otherwise. A total of 387 parasitemic children were categorized as either SMA (n = 165) or non-SMA (n = 222) based on age- and geographically-matched Hb concentrations in children in western Kenya (Hb < 6.0 g/dL, with any density parasitemia) [35]. aStatistical significance determined by Chi-square (χ2) tests. bStatistical significance determined by Mann–Whitney U test. Abbreviations: RBCs - Red blood cells; RDW - Red cell distribution width; MCHC - Mean corpuscular hemoglobin concentration.