Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels

Table 2 The distribution of individual IL-13 promoter genotypes in the clinical groups

Genotypes	Hemoglobin Levels (g/dL)	P value	n (%)	Non-SMA (Hb ≥ 6.0 g/dL) n (%)	SMA (Hb < 6.0 g/dL) n (%)	P value
IL-13 -7402 T > G
TT	6.4 (3.0)	0.744^b	334 (86.3)	194 (87.4)	140(84.8)	0.767^a
TG	6.1 (3.0)		49 (12.7)	26 (11.7)	23 (13.9)
GG	6.2 (2.0)		4 (1.0)	2 (0.9)	2 (1.2)
IL-13 -4729 A > G
GG	6.4 (4.0)	0.521^b	205(53.0)	78 (47.3)	127 (57.2)	0.152^a
GA	6.0 (3.0)	0.521^b	131 (33.9)	63 (38.2)	68 (30.6)	0.152^a
AA	6.2 (3.0)		51 (13.2)	24 (14.5)	27 (12.2)

Data are presented as [n, (8722%)] for proportions of IL-13 promoter variants -7402 T > G and -4729 G > A within the SMA (n = 165) and non-SMA (n = 222) groups based on age- and geographically-matched Hb concentrations in children in western Kenya (Hb < 6.0 g/dL, with any density parasitemia) [35]. ^aChi-square analysis. The Hb levels are presented as medians (IQR), and ^bKruskal Wallis test was used to compare the levels between the genotypes.

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