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Figure 1 | BMC Immunology

Figure 1

From: Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression

Figure 1

Peripheral αβ and γδ T lymphocyte numbers in human CD3G or CD3D haploinsufficiencies. (A) Peripheral blood cell counts from different γ+/−, δ+/− or δ+/leaky individuals are compared with the normal age-matched distribution as mean ± SEM against the P5/P95 normal range (horizontal dashed lines [6]). Asterisks in bars indicate significant differences as compared with controls. p < *0.05, **0.01 or ***0.001. (B) Proportion of αβ (BMA031+) and γδ (Immu510+) T cells (defined as CD3+) in different peripheral blood subsets (CD4+, CD8bright, CD8dull and DN) in healthy individuals. Data are mean ± SD (n = 6).

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