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Figure 4 | BMC Immunology

Figure 4

From: Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression

Figure 4

Simplified model for the effect of human CD3 haploinsufficiencies on TCR assembly and expression. Lack of a CD3γε-fitting structure in TCRγ, as opposed to TCRβ [13] (shown in black), and the resultant lower affinity of the former relative to the latter for the CD3γε dimer (represented by arrows), may explain the stronger impact of decreasing CD3γ (shown with a nick) but not CD3δ availability on surface γδ TCR expression as compared to that of the αβ TCR.

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