Table 2 Impact of differentially expressed microRNA on gene expression in T-cells between MS patients and controls
From: MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS)
microRNA | microRNA microarray | Impact of microRNA on its targets (mRNA microarray) | ||
|---|---|---|---|---|
Fold change MS/Control | P-value | TargetScan | Miranda | |
hsa-miR-494 | 0.14 | 3.1 × 10-05 | 1.2 × 10-24 | 6.0 × 10-81 |
hsa-miR-15b | 0.14 | 2.5 × 10-03 | 4.1 × 10-34 | 5.5 × 10-15 |
hsa-miR-30c | 0.15 | 7.7 × 10-04 | 2.8 × 10-13 | 5.0 × 10-58 |
hsa-miR-23a | 0.16 | 7.8 × 10-03 | 2.2 × 10-23 | 9.8 × 10-63 |
hsa-miR-197 | 0.19 | 5.2 × 10-06 | 1.6 × 10-12 | 1.2 × 10-06 |
hsa-miR-1260b | 0.21 | 9.4 × 10-07 | NA | 2.3 × 10-16 |
hsa-miR-125a-5p | 0.22 | 8.2 × 10-03 | 1.2 × 10-43 | 5.3 × 10-13 |
hsa-miR-361-5p | 0.24 | 1.4 × 10-02 | 1.8 × 10-15 | 3.9 × 10-32 |
hsa-miR-320d | 0.26 | 2.8 × 10-03 | 2.0 × 10-09 | 7.4 × 10-36 |
hsa-miR-423-3p | 0.26 | 1.6 × 10-02 | 5.0 × 10-13 | 1.8 × 10-03 |
hsa-miR-1280 | 0.29 | 4.7 × 10-03 | 8.2 × 10-56 | 8.6 × 10-04 |
hsa-miR-663 | 0.32 | 3.5 × 10-03 | 5.9 × 10-70 | 1.8 × 10-28 |
hsa-miR-423-5p | 0.33 | 2.6 × 10-02 | 6.1 × 10-96 | 5.7 × 10-36 |
hsa-miR-99b | 0.36 | 2.4 × 10-02 | 3.4 × 10-04 | 7.6 × 10-03 |
hsa-miR-339-5p | 0.37 | 4.9 × 10-02 | 1.5 × 10-35 | 2.5 × 10-07 |
hsa-let-7a | 0.37 | 2.9 × 10-02 | 1.9 × 10-04 | 3.2 × 10-09 |
hsa-miR-1979 | 0.38 | 1.2 × 10-02 | NA | 8.1 × 10-09 |
hsa-miR-3178 | 0.39 | 1.0 × 10-02 | NA | NS |
hsa-miR-625 | 0.41 | 3.2 × 10-02 | 3.6 × 10-62 | 2.3 × 10-09 |
hsa-miR-150 | 0.65 | 3.7 × 10-02 | 2.1 × 10-68 | 2.1 × 10-11 |
hsa-miR-3153 | 1.14 | 4.5 × 10-02 | NA | 2.4 × 10-09 |