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Table 3 CD4 + Vβ chains usage in T1DM children

From: Flow cytometric analysis of the CD4+ TCR Vβ repertoire in the peripheral blood of children with type 1 diabetes mellitus, systemic lupus erythematosus and age-matched healthy controls

T1DM children

CD4+ TCR Vβ Increased usage

CD4 + TCR Vβ Decreased usage

Patient 1

Vβ5.1 (7.3%, Μ + 2SD)

None

Patient 2

Vβ5.3 (5.8%, Μ + 3SD)

None

Patient 3

Vβ16 (5%, Μ + 3SD)

None

Vβ5.1 (7.5%, Μ + 2SD)

Vβ8 (6.5%, Μ + 2SD)

Vβ21.3 (4.1%, Μ + 2SD)

Patient 4

None

None

Patient 5

Vβ16 (5.5%, Μ + 3SD)

Vβ14 (0.7%, Μ-2SD)

Vβ18 (4.1%, Μ + 3SD)

Vβ11 (3.1%, Μ + 2SD)

Patient 6

None

None

Patient 7

None

None

Patient 8

Vβ3 (11.2%, Μ + 3SD)

None

Patient 9

Vβ4 (2.6%, Μ + 3SD)

None

Patient 10

None

None

Patient 11

Vβ4 (2.3%, Μ + 2SD)

None

Patient 12

Vβ4 (2.1%, Μ + 2SD)

None

Patient 13

None

None

Patient 14

Vβ4 (2.2%, Μ + 2SD)

None

Patient 15

Vβ5.1 (9.1%, Μ + 3SD)

Vβ20 (0.5%, Μ-2SD)

 

Vβ4(3.3%, Μ + 3SD)

 
  1. CD4 + TCR Vβ repertoire observed in T1DM patients in comparison to controls was similar. Low usage of the Vβ chains is rarely found in patients with T1DM.