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Table 6 Skewing of the CD4 + Vβ repertoire in SLE children

From: Flow cytometric analysis of the CD4+ TCR Vβ repertoire in the peripheral blood of children with type 1 diabetes mellitus, systemic lupus erythematosus and age-matched healthy controls

Patients with ANA & anti-dsDNA

CD4+ TCR Vβ increased usage

CD4 + TCR Vβ decreased usage

Patient 1

None

None

Patient 2

Vβ16 (7.4%, Μ + 3SD)

None

Patient 3

Vβ4 (2.4%, Μ + 3SD)

Vβ18 (0%, Μ-2SD)

Patient 4

Vβ16 (8.2%, Μ + 3SD)

Vβ8 (0.3%, Μ-3SD)

Vβ13.6 (0%, Μ-3SD)

Patient 5

Vβ13.2 (7.4%, Μ + 3SD)

 

Vβ4 (2.7%, Μ + 3SD)

Patient 6

Vβ16 (5.6%, Μ + 3SD)

Vβ5.1 (0.12%, Μ-2SD) Vβ2 (2.83%, Μ-2SD)

Vβ20 (9.17%, Μ + 3SD)

Vβ12 (9.44%, Μ + 3SD)

Patient 7

None

None

Patient 8

Vβ16 (8%, Μ + 3SD)

Vβ22 (0%, Μ-2SD)

Vβ20 (7.5%, Μ + 2SD)

Patient 9

Vβ3 (9%, Μ + 2SD)

Vβ7.1 (0.1%, Μ-2SD) Vβ5.2 (0.2%, Μ-2SD) Vβ2 (0.2%, Μ-2SD) Vβ22 (0.3%, Μ-2SD)

Vβ16 (7.3%, Μ + 3SD)

 

Vβ12 (14.2%, Μ + 3SD)

 
  1. Discrepancies of the CD4+ TCR Vβ repertoire observed in SLE patients at initial diagnosis. M mean value (derived from controls sample), SD standard deviation.
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BMC Immunology

ISSN: 1471-2172

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