Local and systemic neutrophilic inflammation in patients with lung cancer and chronic obstructive pulmonary disease

Table 1 Characteristics of subjects

Variable	Lung cancer group		Control group
Variable	Without COPD n = 139	With COPD n = 55	COPD n = 40	Healthy individuals n = 33
Gender^a
Male	103 (74.1)	50 (90.9)	36 (90.0)	24 (72.7)
Female	36 (25.9)	5 (9.1)	4 (10.0)	9 (27.3)
Age, mean ± SEM, years	63.1 ± 0.9	64.5 ± 1.2	65.4 ± 1.2	62.6 ± 0.9
BMI, mean ± SEM, kg/m²	27.3 ± 0.4	26.9 ± 0.5	28.4 ± 0.6	26.7 ± 0.6
Smoking history^aa
Never smoker	30 (21.6)	0	0	11 (33.3)
Former smoker	27 (19.4)	7 (12.7)	19 (47.5)	10 (30.3)
Current smoker	82 (59.0)	48 (87.3)	21 (52.5)	12 (36.4)
Smoking pack-years, median (range):
Former smoker	28.0 (10–54)	30.0 (15–40)	33.0 (13–57)	22.0 (11–44)
Current smoker	38.0 (10–60)	40.0 (12–60)	39.5 (10–94)	32.0 (20–56)
FEV_1, mean ± SEM, % pred	91.2 ± 1.7*	56.7 ± 1.6^§	55.7 ± 2.3^§	106.6 ± 3.0
FEV₁/FVC ratio, mean ± SEM, % pred	96.6 ± 0.7*	70.6 ± 1.1^§	74.0 ± 1.8^§	104.8 ± 0.4

FEV₁ forced expiratory volume in one second, FVC forced vital capacity, BMI body mass index, COPD chronic obstructive pulmonary disease.
*P < 0.05, when compared to lung cancer with COPD, COPD, and healthy individuals groups.
^§P < 0.05, when compared with healthy individuals.
^aχ²-10.61, P < 0.05.
^aaχ²-48.14, P < 0.001.

ISSN: 1471-2172