Skip to main content
Figure 2 | BMC Immunology

Figure 2

From: CAWS administration increases the expression of interferon γ and complement factors that lead to severe vasculitis in DBA/2 mice

Figure 2

Expression profiling of microarray data for complement system genes following administration of CAWS to B6 and DBA/2 mice. (A) Mosaic tile representation of genes involved in the complement system. B6 and DBA/2 samples were clustered using a hierarchical clustering program (Spearman) to identify gene-to-gene relationships. Intensity gradients indicate the mean value of the expression level (log2 ratio): blue (down-regulation) and crimson (upregulation) are shown compared to the average value at week 0 (0 w) after CAWS administration (gray). C3ar1, Fcna, C4, Cfb, Cfh, and C3 genes are highlighted by turquoise arrows. (B) Scatter plots of the log of signal intensity at 2 w (top panel) or 4 w (bottom panel) versus 0 w of CAWS administration in DBA/2 mice. Data are plotted over the entire signal intensity range to demonstrate that these expression arrays provide a high-resolution platform. C3ar1, Fcna, C4, Cfb, Cfh, and C3 genes are highlighted in red font.

Back to article page

BMC Immunology

ISSN: 1471-2172

Contact us