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Figure 5 | BMC Immunology

Figure 5

From: Differential requirement for Hoxa9 in the development and differentiation of B, NK, and DC-lineage cells from Flt3+ multipotential progenitors

Figure 5

Model depicting Hoxa9 and Flt3 expression patterns in DC, NK, and B cell precursors in BM. HSC, MPP, GMLP and LMPP are primitive LSK+ subsets defined by differential expression of Flt3 and VCAM-1[46]. CLP are Lin-ckitloIL-7R+Flt3+Ly6D-. BLPs are a B lineage restricted subset of CLP/ALP that express Ly6D. ProB through PreB are B220+ B cell progenitor subsets. PreNKP are Lin-CD244+CD27+IL-7R+Flt3-loCD122- and are the presumed progeny of CLP/ALP. rNKP through mNK are NK lineage restricted subsets distinguish based on expression of CD122, NK1.1 and Dx5. Hoxa9 and Flt3 expression patterns within the subsets are derived from our previous study[4], or deduced from the Immunological Genomic Project database (http://www.immgen.org/databrowser/index.html).

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BMC Immunology

ISSN: 1471-2172

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