Relative mRNA expression levels from ear biopsies of TPA treated mice. Left columns depict Box-plot with whiskers (5–95 percentile) of the relative mRNA expression levels (Vehicle only mice index 1). On graphs statistical differences (Mann Whitney test) marked by p-value or as n.s. (non significant) between scrambled and CKS-17 treated mice. Right column depicts xy-plots of the Log10 normalized relative mRNA expression and ear thickness. Linear relationships were determined by Spearman correlation.