Budesonide suppresses pulmonary antibacterial host defense by down-regulating cathelicidin-related antimicrobial peptide in allergic inflammation mice and in lung epithelial cells

Table 1 The extent of lung inflammation were analyzed by microscopical histopathologic scoring 24 h after intrartracheal challenge with P. aeruginosa

Treatment group	No. of mice with the following lung pathology score/total no. of mice (%)			Lungabscess incidence
	1+2	3	4	(%)
Control	9/10(90)	1/10(10)	0	0
OVA	3/10(30)	6/10(60)	1/10(10)	10
OVA/P.a	0	7/10(70)	3/10(10)	30
ONA/BUD	7/10(70)	3/10(30)	0	0
OVA/BUD/P.a	0	3/10(30)	7/10(60)**	70**

The cellular infiltration scoring of OVA/Bud mice was lower than that in OVA. The scoring of OVA/Bud/P. a mice was higher than that in OVA/P. a *p<0.001 compared to OVA; **p<0.001 compared to OVA/.a.