Table 2 Baseline immunological marker values of 81 PHID patients, ALTADIH Cohort 2007-2010
Unit | Median | IQR | ||
|---|---|---|---|---|
Total circulating lymphocytes (TCL) | cells/mm3 | 1384 | (1017, 2000) | |
B cells | CD19+ | cells/mm3 | 128 | (62, 193) |
% TCL | 9.37 | (6.21, 12.91) | ||
Naïve | CD27-IgD+ | % CD19+ | 74.01 | (56.42, 83.35) |
Switched | CD27-IgD- | % CD19+ | 2.62 | (1.86, 5.16) |
Marginal zone | CD27 + IgD+ | % CD19+ | 9.42 | (4.70, 15.37) |
Switched memory | CD27 + IgD- | % CD19+ | 8.07 | (3.63, 19.45) |
T cells | CD3+ | cells/mm3 | 1078 | (746, 1585) |
CD4+ | cells/mm3 | 657 | (422, 941) | |
CD8+ | cells/mm3 | 329 | (228, 524) | |
CD4+/CD8+ ratio | 1.99 | (1.30, 2.70) | ||
CD8+ T cells | ||||
Naïve | CD45RA + CCR7+ | % CD8+ | 18.01 | (6.79, 36.07) |
Central memory | CD45RA-CCR7+ | % CD8+ | 1.25 | (0.59, 2.48) |
Effector memory | CD45RA-CCR7- | % CD8+ | 34.39 | (24.47, 46.90) |
Terminal effector | CD45RA + CCR7- | % CD8+ | 33.48 | (23.31, 48.26) |
Immunosenescent | CD8 + CD57+ | % CD8+ | 15.97 | (8.04, 31.75) |
Activated T cells | ||||
HLA-DR | CD3 + HLA-DR+ | % CD3+ | 12.87 | (7.99, 20.37) |
CD4 + HLA-DR+ | % CD4+ | 7.96 | (5.14, 13.79) | |
CD8 + HLA-DR+ | % CD8+ | 24.49 | (14.31, 41.11) | |
Regulatory T cells | CD4 + CD25 + CD127- | cells/mm3% TCL | 32 1.10 | (16, 63) (0.51, 1.76) |
Natural Killer cells | CD3-CD16 + CD56+ | cells/mm3 | 126 | (75, 194) |
Dendritic cells | ||||
Myeloid | mDC | /ml | 9381 | (6597, 15611) |
Plasmacytoid | pDC | /ml | 4671 | (2810, 7427) |
Gammadelta cells | cells/mm3 | 33 | (15, 72) | |
Gammadelta 2 cells | % GD | 56.32 | (22.19, 77.17) | |