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Table 3 Baseline immunological characteristics of 5 clusters of 79 PHID patients, ALTADIH Cohort, 2007-2010

From: T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults

  

Cluster 1

Cluster 2

Cluster 3

Cluster 4

Cluster 5

n = 33

n = 18

n = 4

n = 8

n = 16

IgG

g/L

4.37 (3.80, 5.32)

5.73 (4.7, 6.3)

4.68 (2.69, 5.29)

1.44 (0.30, 2.71)

3.69 (1.65, 4.22)

IgA

g/L

0.63 (0.14, 1.62)

1.02 (0.07, 1.55)

0.60 (0.04, 2.09)

0.15 (0.01, 0.43)

0.19 (0.05, 0.79)

IgM

g/L

0.55 (0.31, 1.09)

0.48 (0.24, 0.78)

0.54 (0.34, 0.62)

0.16 (0.05, 0.42)

0.27 (0.20, 0.47)

B cells

      

CD19+

cells/mm3

157 (128, 244)

128 (102, 211)

49 (20, 87)

122 (94, 176)

51 (29, 119)

CD27-IgD+

% CD19+

68.85 (52.03, 74.47)

68.89 (57.94, 77.24)

49.52 (10.73, 80.43)

90.89 (82.94, 93.31)

84.03 (70.93, 90.82)

CD27-IgD-

% CD19+

2.80 (2.18, 4.38)

3.90 (2.24, 6.42)

6.13 (2.64, 23.40)

2.40 (1.67, 2.58)

2.65 (1.72, 4.22)

CD27 + IgD+

% CD19+

15.01 (10.11, 23.19)

10.53 (4.42, 13.73)

5.67 (2.43, 8.57)

3.57 (2.21, 7.20)

4.92 (1.32, 7.92)

CD27 + IgD-

% CD19+

14.39 (7.08, 20.05)

13.93 (7.26, 24.33)

7.77 (2.43, 19.38)

2.55 (0.94, 3.91)

2.97 (0.36, 6.66)

T cells

      

CD3+

cells/mm3

1363 (1076, 1787)

1045 (883, 1456)

2756 (1472, 4183)

831 (658, 1075)

579 (407, 837)

CD4+

cells/mm3

835 (571, 1214)

789 (573, 967)

848 (609, 1227)

382 (302, 565)

308 (244, 565)

CD8+

cells/mm3

477 (358, 604)

270 (159, 383)

1621 (710, 2682)

293 (196, 362)

213 (141, 266)

CD4+/CD8+ ratio

 

1.89 (1.45, 2.42)

2.77 (2.31, 4.08)

0.60 (0.42, 1.06)

1.26 (0.67, 2.65)

1.89 (1.17, 2.61)

CD8+ T cells

      

CD45RA + CCR7+

% CD8+

19.05 (11.11, 34.59)

28.47 (13.32, 43.67)

1.52 (0.56, 2.75)

4.91 (1.53, 53.19)

35.56 (10.29, 53.19)

CD45RA-CCR7+

% CD8+

0.83 (0.46, 1.90)

4.60 (1.96, 7.97)

0.53 (0.21, 0.82)

0.82 (0.30, 1.20)

1.37 (0.85, 1.96)

CD45RA-CCR7-

% CD8+

31.28 (24.26, 36.96)

43.13 (32.60, 57.14)

36.82 (16.56, 57.25)

39.24 (30.69, 59.20)

29.14 (17.47, 42.55)

CD45RA + CCR7-

% CD8+

41.48 (32.61, 52.32)

22.30 (16.87, 27.10)

40.75 (13.96, 59.90)

48.28 (30.47, 63.41)

29.25 (18.76, 39.37)

CD8 + CD57+

% CD8+

17.52 (9.42, 30.97)

7.38 (4.41, 15.97)

27.36 (19.36, 47.30)

39.61 (33.78, 51.16)

13.51 (8.35, 23.44)

Activated T cells

      

CD3 + HLA-DR+

% CD3+

12.04 (7.62, 16.95)

9.87 (7.11, 12.83)

52.00 (32.71, 59.56)

46.56 (40.76, 57.25)

13.65 (6.19, 20.33)

CD4 + HLA-DR+

% CD4+

5.88 (4.94, 9.17)

6.75 (4.95, 9.13)

48.30 (26.32, 56.25)

43.87 (30.88, 49.95)

11.54 (6.52, 18.33)

CD8 + HLA-DR+

% CD8+

25.48 (14.86, 31.93)

19.73 (14.18, 26.44)

53.48 (37.05, 65.52)

62.14 (47.01, 76.39)

15.12 (10.65, 28.64)

Regulatory T cells

cells/mm3

54 (33, 76)

41 (24, 82)

18 (13, 22)

19 (12, 24)

15 (8, 18)

NK cells

cells/mm3

143 (100, 214)

174 (121, 230)

268 (146, 388)

75 (55, 103)

41 (26, 70)

Dendritic cells

      

Myeloid

/ml

11940 (8751, 17805)

11422 (6616, 13457)

9122 (5662, 29989)

7795 (4086, 10548)

5420 (4107, 9683)

Plasmacytoid

/ml

7217 (4801, 11084)

6152 (3599, 9836)

2771 (1766, 8490)

3073 (1351, 3618)

2766 (2194, 4255)

Gammadelta cells

cells/mm3

44 (20, 74)

27 (11, 54)

396 (178, 579)

19 (6, 92)

16 (9, 26)

Gammadelta 2

% GD

62.96 (40.85, 73.68)

78.71 (75.00, 89.39)

13.40 (8.77, 30.62)

6.59 (4.09, 25.61)

25.00 (12.41, 55.96)

  1. Results are expressed as medians (interquartile range values).