Table 5 Immunological markers association with CVID complications
Unit | Odds ratio | 95% confidence interval | p-value | |
|---|---|---|---|---|
B cells | ||||
CD19+ | cells/mm3 | 0.65 | [0.36; 1.15] | 0.1373 |
CD27-IgD+ | % CD19+ | 1.49 | [0.89; 2.48] | 0.1310 |
CD27-IgD- | % CD19+ | 0.54 | [0.24; 1.23] | 0.1401 |
CD27 + IgD+ | % CD19+ | 0.62 | [0.34; 1.12] | 0.1124 |
CD27 + IgD- | % CD19+ | 0.93 | [0.29; 0.86] | 0.0119 |
T cells | ||||
CD3+ | cells/mm3 | 0.68 | [0.40; 1.17] | 0,1646 |
CD4+ | cells/mm3 | 0.45 | [0.26; 0.78 ] | 0,0046 |
CD8+ | cells/mm3 | 1.04 | [0.66; 1.62 ] | 0.8818 |
CD4+/CD8+ ratio | 0.99 | [0.63; 1.56 ] | 0.9649 | |
CD8+ T cells | ||||
CD45RA + CCR7+ | % CD8+ | 0.69 | [0.43; 1.13] | 0.1385 |
CD45RA-CCR7+ | % CD8+ | 0.75 | [0.46; 1.25] | 0.2710 |
CD45RA-CCR7- | % CD8+ | 1.38 | [0.86; 2.20] | 0.1800 |
CD45RA + CCR7- | % CD8+ | 0.77 | [0.48; 1.23] | 0.2666 |
CD8 + CD57+ | % CD8+ | 1.30 | [0.83; 2.06] | 0.2567 |
Activated T cells | ||||
CD3 + HLA-DR+ | % CD3+ | 2.99 | [1.56; 5.73] | 0.0010 |
CD4 + HLA-DR+ | % CD4+ | 2.70 | [1.40; 5.23] | 0.0032 |
CD8 + HLA-DR+ | % CD8+ | 2.75 | [1.54; 4.90] | 0.0006 |
Regulatory T cells | cells/mm3 | 0.41 | [0.22; 0.78] | 0.0065 |
Natural Killer cells | cells/mm3 | 0.75 | [0.46; 1.21] | 0.2369 |
Dendritic cells | ||||
Myeloid | /ml | 0.65 | [0.36; 1.17] | 0.1532 |
Plasmacytoid | /ml | 0.37 | [0.18; 0.73] | 0.0046 |
Gammadelta cells | cells/mm3 | 1.30 | [0.79; 2.13] | 0.3028 |
Gammadelta 2 cells | % GD | 0.52 | [0.32; 0.85] | 0.0087 |