T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults

BMC Immunology

Table 6 Reclassification of 55 CVID patients smB+/-, separated according to experience of complications

Model with EUROclass	Model with EUROclass and CD8+ HLA-DR+		Total
Predicted probabilities (%)	< 50%	≥ 50%
Patients who experienced CVID complications
< 50%	9		19
≥ 50%	1	5	6
Total	10	15	25
Patients who didn’t experience CVID complications
< 50%	22	5	27
≥ 50%	2	1	3
Total	24	6	30

ALTADIH Cohort, 2007-2010.
The agreements between the two models for classifying the patients are depicted in gray. Adding CD8 + HLA-DR + to EUROclass model leads to better determine CVID complications for 10 patients who experienced CVID complications (upward movement in category for patients who experienced CVID complications) and to better determine the absence of CVID complications for 2 patients who did not experience CVID complications (downward movement in category for patients who did not experience CVID complications). In parallel, it leads to worsened classification for 1 patient who experienced CVID complications (downward movement in category for patients who did experience CVID complications) and 5 patients who did not experience CVID complications (upward movement in category for patients who did not experience CVID complications).
The positive net reclassification improvement (0.26) revealed that CD8+ HLA-DR + offers improved prediction of CVID complications.

ISSN: 1471-2172