Figure 1

IL-33 is reduced in non-lean subjects. The concentration of serum IL-33 was measured in lean (n = 10) and non-lean (n = 21, 8 overweight and 13 obese) non-diabetic subjects. (a) Non-lean subjects had significantly (P = 0.01, non-parametric Mann-Whitney test) lower concentrations of IL-33 compared to lean controls. The graph shows the median of the 'minimum to maximum' IL-33 values. (b) Overweight subjects had significantly (P = 0.003, non-parametric Mann-Whitney test; the overall non-parametric Kruskal-Wallis test was P = 0.01) lower concentrations of IL-33 compared to lean controls. The graph shows the median of the ⁄minimum to maximum’ IL-33 values. (c) IL-33 is negatively correlated with the BMI in non-diabetic subjects, which was confirmed in lean/overweight (n = 18; Spearman r = -0.76, P = 0.0003) but not obese (n = 13; body weight: Spearman r = -0.115, P = 0.7; BMI: Spearman r = 0.08, P = 0.8) subjects. (d) IL-33 is negatively correlated with the body weight (n = 31; Spearman r = -0.38, P = 0.034) in non-diabetic subjects, which was confirmed in lean/overweight (n = 18; Spearman r = -0.57, P = 0.013) but not obese (n = 13) subjects.