Figure 1

Immunological assessment for Study 1. (A) Three randomly selected mice from each of the groups were used for immunologic assessments (the numbers next to each dot represent the mouse number). ANOVA showed that anti-DNA autoantibody levels was significantly different between the groups (F = 112.953, p < 0.001) and using post-hoc analysis at p < 0.001 the 4 month MRL/lpr had significantly greater anti-DNA antibody levels compared to controls (measured at 1:800 serum dilution). (B) For the spleen weights there was a significant difference between the groups (F = 18.365, p < 0.003) and post-hoc analysis at p < 0.007 revealed that the 4 month MRL/lpr had significantly greater spleen weights (per body weight) compared to the MRL/mp and C3H/HeJ. In the box plot the middle line is the 50^th percentile, the top of the box is the 75^th percentile and the bottom of the box is the 25^th percentile.