TY - JOUR AU - VanGundy, Zachary C. AU - Guerau-de-Arellano, Mireia AU - Baker, Julie D. AU - Strange, Heather R. AU - Olivo-Marston, Susan AU - Muth, Dillon C. AU - Papenfuss, Tracey L. PY - 2014 DA - 2014/02/18 TI - Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells JO - BMC Immunology SP - 8 VL - 15 IS - 1 AB - Myeloid cells (MC) have potent immunoregulatory abilities that can be therapeutically useful to treat inflammatory disease. However, the factors which promote regulatory myeloid cell differentiation remain poorly understood. We have previously shown that estriol (E3) induces mature regulatory dendritic cells in vivo. To determine whether additional steroid hormones could induce mature regulatory myeloid cells, we investigated the effects of retinoic acid (RA) on MCs. Retinoic acid is a steroid hormone important in regulating mucosal immunity in the gut and promoting myeloid differentiation. We hypothesized that the presence of RA during differentiation would promote the formation of mature regulatory myeloid cells (MCregs). SN - 1471-2172 UR - https://doi.org/10.1186/1471-2172-15-8 DO - 10.1186/1471-2172-15-8 ID - VanGundy2014 ER -