TY - JOUR AU - Wang, Shui-Bin AU - Deng, Yu-Qin AU - Ren, Jie AU - Xiao, Bo-Kui AU - Liu, Zheng AU - Tao, Ze-Zhang PY - 2014 DA - 2014/02/25 TI - Exogenous interleukin-10 alleviates allergic inflammation but inhibits local interleukin-10 expression in a mouse allergic rhinitis model JO - BMC Immunology SP - 9 VL - 15 IS - 1 AB - Interleukin-10 (IL-10) has an important anti-inflammatory and immunoregulatory function, and its expression is negatively correlated with the development and severity of allergic rhinitis (AR). However, the in vivo effects of exogenous IL-10 on AR have not been studied and the mechanisms underlying the effects of IL-10 have not been fully understood. Here, we investigated the effects of intranasal administration of recombinant mouse (rm) IL-10 on the expression of Th responses and local IL-10 in a mouse model of AR induced by ovalbumin. SN - 1471-2172 UR - https://doi.org/10.1186/1471-2172-15-9 DO - 10.1186/1471-2172-15-9 ID - Wang2014 ER -