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Figure 4 | BMC Immunology

Figure 4

From: Exogenous interleukin-10 alleviates allergic inflammation but inhibits local interleukin-10 expression in a mouse allergic rhinitis model

Figure 4

rmIL-10 reduced local IL-10 expression in nasal mucosa. IL-10 immunohistochemistry for IL-10-positive cells in the nasal mucosa of mice was carried out by using the streptavidin-biotin complex method. Representative photomicrographs (original magnification × 400) of IL-10 immunohistochemical staining of nasal mucosa sections from the control mice (A), AR mice (B), and AR mice treated with rmIL-10 (C), and sections stained with negative control for anti-IL-10 antibody (E). A representative photomicrograph with enlarged magnification (original magnification × 1000) of IL-10 immunohistochemical staining of nasal mucosa sections from AR mice (D). The number of IL-10-positive cells was significantly higher in the AR group compared with the control group, and it was reduced in the AR group compared with the IL-10 group (F). Control group, saline-sensitized and challenged mice; AR group, OVA-sensitized and challenged mice; IL-10 group, AR mice were treated with rmIL-10 during challenge.

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BMC Immunology

ISSN: 1471-2172

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