Comparison of KRC-selected sequence with IgVκ and TCRAJ RSS elements. The KRC-bound sequences were compared to known RSS sequence in the murine TCR-alpha genes and the human immunoglobulin heavy chain genes, the loci of which have been fully sequenced [45, 46]. Individual sequences in the training sets were compared manually with (A) RSS nonamers or (B) RSS hepamers defined in of the human Ig variable region gene segments of κ light chain (Table 1 of ) and the mouse TCRAJ gene segments (Fig. 2 of ). The nucleotide sequence of a RSS nonamer or heptamer was listed in the first column, followed by the name of the site selected sequence(s), and then by the gene segments with matching RSS elements. Sequence in the KRC fusion protein-bound oligonucleotides overlapped with heptamer, nonamer, or both in the RSS of 43.3% of human IgVκ genes and in 33.9% of murine TCRAJ genes. These calculations include only the IgVκ  and TCRAJ genes  which contain a nonamer, a heptamer, or both.