Figure 16

Comparison of KRC protein zinc finger domains. The zinc finger amino acid sequences of the KRC ZAS domains are compared. Mouse and human KRC ZAS-N amino acid sequences are aligned above the corresponding mouse and human KRC ZAS-C sequence. Above the sequences, the C and H represent the canonical Cys and His residues of the C₂H₂ domains, and the numbers represent the position within the alpha helix. The consensus sequence is derived from sequence analysis of all the known ZAS protein sequences [25]. The zinc finger 1 and zinc finger 2 domains within the ZAS domains are designated in green and blue font, respectively, in the consensus sequence. Amino acid residues that are common to all ZAS family members are capitalized. The critical amino acid residues within the α helical regions of the zinc finger regions are identical at all corresponding positions between the first and second zinc fingers of the ZAS-N and ZAS-C domains except at position 3 of the first zinc finger (outlined in gray) and at position 2 of the second zinc finger (outlined in gray). The linker region between the two zinc fingers is outlined in red.