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Figure 5 | BMC Immunology

Figure 5

From: Human CD81 directly enhances Th1 and Th2 cell activation, but preferentially induces proliferation of Th2 cells upon long-term stimulation

Figure 5

CD81 costimulation results in the accumulation of IL-4-producing CD4 T cells over time. CD45RO+ cells were stimulated with plate-bound anti-CD3 mAb in the presence or absence of 10 μg/ml 5A6 anti-CD81 mAb for 1, 3, or 7 days. They were then restimulated for 4 h with PMA+ionomycin, and cytokine-producing T cells were enumerated by intracellular staining. (A) The absolute number of IL-4-producing CD4 T cells increases more dramatically over time in the presence of anti-CD81 mAb than in its absence. (B) The absolute number of IFNγ-producing CD4 T cells is similar over time in cultures incubated with or without anti-CD81 mAb. Error bars represent S.D. Results are representative of two similar experiments.

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BMC Immunology

ISSN: 1471-2172

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