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Table 4 Molecular weights (kDa) of the class I and II soluble MHC antigen species detected in rodents and humans. Comparison with four molecular species of similar MW detected in paternal serum using the immunoblot test with anti-chick embryo antibodies, adsorbed with hen serum.

From: Detection in chick embryo of fetoproteins not recognized by the dam's immune system and of soluble alloantigens. Presumptive teratogenic and abortogenic capacity of their specific IgY

sHLA/2-m class I

beta 2-m

sHLA-HC class Ia

sHLA-HC class Ib

sHLA-HC class Ic

sHLA class II

Reference and animal speciesd

 
 

11

44

 

33

 

47

H

  

43

39

  

48

H

  

44

40

37–35

 

49

H

200

     

50

H

  

44

39–36

34

 

51

H

 

12

 

39

33

 

52

H

    

36

 

30

H

   

39 non-RT1.A associated with β-2 m

36 RT1.Aa

 

53

R

  

43

39

35

 

54

H

     

70

35

M

200

  

34

32

70

TWe

A

  1. aThe heaviest species resulted from cell shedding and included a transmembrane segment and cytoplasmic tail bThe intermediate species resulted from alternate splicing transcript and contained no transmembrane piece cThe lightest species contained neither a transmembrane piece nor a cytoplasmic tail dH = human, R = rat, M = mouse, A = avian, TW = this work eThe author does not prejudge here which MHC class or group the sAlloAg detected in this work belong to