Figure 1

CpG ODN mediated up-regulation of a gene cluster in PBMC. A gene cluster containing 77 genes was up-regulated more than two-fold in PBMC after stimulation with CpG ODN. Data were analyzed by applying a hierarchical-tree algorithm to the normalized intensity. The color code for the signal strength in the classification scheme is shown in the box on the left. Induced genes are indicated by shades of red; repressed genes are indicated by shades of blue. Exactly the same experiments were performed with PBMCs from three individual donors to confirm the reproducibility of the present experiments. All of these genes were consistently included in a CpG-inducible cluster in the same fashion even though cRNA elongation was not completed in a single experiment. * GenBank accession number