Figure 1

Effect of p50 deficiency on neutrophil recruitment elicited by LPS in the lungs. E. coli LPS was instilled intratracheally to WT and p50-deficient mice, and lungs and blood were collected after 24 hours. Representative histologic images from lungs of WT and p50-deficient mice are shown (A and B, respectively). Emigrated neutrophils (C) in the alveolar air spaces, and sequestered neutrophils (D) in the alveolar septae, were quantified using morphometric analyses of histologic sections. Circulating neutrophils (E) were quantified in blood samples collected from the inferior vena cava. Asterisks (*) denote significant differences from WT mice.